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Background: Inflammation and accumulation of macrophages are key features of unstable atherosclerotic plaques. The ability of macrophages to take up molecular probes can be exploited in new clinical imaging methods for the detection of unstable atherosclerotic lesions. We investigated whether modifications of human serum albumin HSA could be used to target macrophages efficiently in vitro. Fluorescent or radiolabeled Zr modified HSA was used in in vitro experiments to study cellular uptake by differentiated THP-1 cells and primary human macrophages.

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